Believed to affect about 1 in 42,000 people, Waardenburg Syndrome is characterized by a degree of hearing loss and a lack of pigmentation, which can include bright blue eyes (or one blue eye and one eye). black, brown).
This syndrome is caused by a mutation in any of the genes that affects the activity of nerve crest cells during embryo development. In the photos of Buton tribe members taken by Indonesian geologist and amateur photographer Korchnoi Pasaribu, it can be seen that this syndrome is quite strange but it brings an unbelievable beauty.
People with Waardenburg Syndrome often have very pale blue eyes or two different colored eyes. Sometimes an eye has sections of two different colors. Other common facial features include a wide eye gap due to a wide base of the nose, low hairline, or an eyebrow touching the middle. Waardenburg syndrome is associated with a higher than average association with intestinal and spinal defects, cleft palate and palate, and white pigmentation patches on the skin similar to vitiligo.
Waardenburg syndrome is usually inherited in a chromosomal dominant gene, meaning that only one copy of the defective gene is needed to cause the disorder. In most cases, a child has Waadenburg syndrome when a mother or father has this genetic disorder. A small proportion of cases are caused by a new gene mutation, in which there is no history of the disorder in the affected person’s family.